Under the Radar: Epidemiology of Plasmodium ovale in the Democratic Republic of the Congo.

ABSTRACT:

Background

Plasmodium ovale is an understudied malaria species prevalent throughout much of sub-Saharan Africa. Little is known about the distribution of ovale malaria and risk factors for infection in areas of high malaria endemicity.

Methods

Using the 2013 Democratic Republic of the Congo (DRC) Demographic and Health Survey, we conducted a risk factor analysis for P. ovale infections. We evaluated geographic clustering of infections and speciated to P. ovale curtisi and P. ovale wallikeri through deep sequencing.

Results

Of 18 149 adults tested, we detected 143 prevalent P. ovale infections (prevalence estimate 0.8%; 95% confidence interval [CI], .59%-.98%). Prevalence ratios (PR) for significant risk factors were: male sex PR = 2.12 (95% CI, 1.38-3.26), coprevalent

SUBMITTER: Mitchell CL 

PROVIDER: S-EPMC8006425 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature