Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC8006431 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Yang Fan F Kou Junjie J Liu Zizhao Z Li Wei W Du Wenjing W
Frontiers in cell and developmental biology 20210311
Oncogene c-<i>Myc</i> (referred in this report as <i>MYC</i>) promotes tumorigenesis in multiple human cancers. MYC regulates numerous cellular programs involved in cell growth and cell metabolism. Tumor cells exhibit obligatory dependence on cholesterol metabolism, which provides essential membrane components and metabolites to support cell growth. To date, how cholesterol biosynthesis is delicately regulated to promote tumorigenesis remains unclear. Here, we show that MYC enhances cholesterol ...[more]