Low expression of HIV genes in podocytes accelerates the progression of diabetic kidney disease in mice.

ABSTRACT: With the widespread use combination antiretroviral therapy, there has been a dramatic decrease in HIV-associated nephropathy. However, although the patients living with HIV have low or undetectable viral load, the prevalence of chronic kidney disease (CKD) in this population remains high. Additionally, improved survival is associated with aging-related comorbidities such as diabetes and cardiovascular disease. A faster progression of CKD is associated with concurrent HIV infection and diabetes than with HIV infection or diabetes alone. To explore the potential pathogenic mechanisms that synergistically drive CKD progression by diabetes and HIV infection, we generated a new mouse model with a relatively low expression of HIV-1 proviral genes specifically in podocytes (pod-HIV mice) to bette

SUBMITTER: Feng J 

PROVIDER: S-EPMC8006538 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature