Severe obesity is associated with liver disease severity in pediatric non-alcoholic fatty liver disease.

ABSTRACT:

Background

Paediatric non-alcoholic fatty liver disease (NAFLD) is highly prevalent among children with obesity. The primary objective of this study was determining whether obesity severity is associated with NAFLD severity. By using paediatric classifications for severe obesity, clinicians may be able to better risk stratify patients, which in turn would guide more effective management and treatment.

Methods

Retrospective cohort study including patients followed at Cincinnati Children's Medical Center for NAFLD. Patients were categorized as overweight or class I, II, III obese based on established body mass index (BMI) cut-offs. Liver disease severity was determined using biochemical, imaging (magnetic resonance elastography [MRE]), and histologic evidence of liver injury.<

SUBMITTER: Seth A 

PROVIDER: S-EPMC8006543 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature