Striatal spreading depolarization: Possible implication in levodopa-induced dyskinetic-like behavior.

ABSTRACT:

Objective

Spreading depolarization (SD) is a transient self-propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson's disease (PD) pathophysiology, has been poorly investigated.

Methods

We characterized the participation of glutamatergic and dopaminergic transmission in the induction of striatal spreading depolarization by using a novel approach combining optical imaging, measurements of endogenous DA levels, and pharmacological and molecular analyses.

Results

We found that

SUBMITTER: de Iure A 

PROVIDER: S-EPMC8006568 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature