Heart rate kinetics during standard cardiopulmonary exercise testing in heart transplant recipients: a longitudinal study.

ABSTRACT:

Aims

Heart transplantation (HTx) results in complete autonomic denervation of the donor heart, causing resting tachycardia and abnormal heart rate (HR) responses to exercise. We determined the time course of suggestive cardiac reinnervation post HTx and investigated its clinical significance.

Methods and results

Heart rate kinetics during standard cardiopulmonary exercise testing at 2.5-5 years after HTx was assessed in 58 patients. According to their HR increase 30 s after exercise onset, HTx recipients were classified as denervated (slow responders: <5 beats per minute [b.p.m.]) or potentially reinnervated (fast responders: ≥5 b.p.m.). Additionally, in 30 patients, longitudinal changes of maximal oxygen consumption and HR kinetics were assessed during the first 15 post-ope

SUBMITTER: Schumacher O 

PROVIDER: S-EPMC8006603 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature