On the Consistency between Gene Expression and the Gene Regulatory Network of Corynebacterium glutamicum.

ABSTRACT: Background: Transcriptional regulation of gene expression is crucial for the adaptation and survival of bacteria. Regulatory interactions are commonly modeled as Gene Regulatory Networks (GRNs) derived from experiments such as RNA-seq, microarray and ChIP-seq. While the reconstruction of GRNs is fundamental to decipher cellular function, even GRNs of economically important bacteria such as Corynebacterium glutamicum are incomplete. Materials and Methods: Here, we analyzed the predictive power of GRNs if used as in silico models for gene expression and investigated the consistency of the C. glutamicum GRN with gene expression data from the GEO database. Results: We assessed the consistency of the C. glutamicum GRN using real, as well as simulated, e

SUBMITTER: Parise D 

PROVIDER: S-EPMC8006670 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature