Iron deficiency impacts prognosis but less exercise capacity in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Whether and how iron deficiency (ID) impacts patients with heart failure (HF) with preserved ejection fraction (HFpEF) remain unclear. The aim of our study was to investigate the impact of ID on functional status, exercise capacity, and prognosis in HFpEF.

Methods and results

The study population consisted of 300 HFpEF patients. ID was defined as serum ferritin <100 μg/L or 100-300 μg/L and transferrin-saturation <20%. Baseline functional status, quality of life (HADS score and EQ 5D index), 6 min walking test, echocardiography, and outcome (all-cause mortality and combined all cause-mortality and HF hospitalization) were evaluated. ID was found in 159 (53%) patients. Patients with ID had a worse prognosis with a higher combined endpoint of all-cause mortality and HF ho

SUBMITTER: Barandiaran Aizpurua A 

PROVIDER: S-EPMC8006701 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature