Early changes in bone turnover predict longer-term changes in bone mineral density but not trabecular bone score in frail older women.

ABSTRACT: Clinicians and patients want to know if therapy is working early in their course of treatment. We found that early changes in bone turnover markers at 6 months were associated with long-term changes in bone mineral density but not trabecular bone score at 12 and 24 months.

Purpose

We sought to examine the association between shorter-term changes in markers of bone turnover and longer-term changes in bone mineral density (BMD) and microstructure in a cohort of frail elderly women with multiple comorbid conditions including osteoporosis.

Methods

We performed a secondary analysis of a 2-year zoledronic acid trial for osteoporosis in 155 women residents of long-term care communities (mean age 86.9 years). We examined the association of the 6-month change in serum C-terminal cross

SUBMITTER: Kotlarczyk MP 

PROVIDER: S-EPMC8006805 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature