Isolation and Characterization of <i>Klebsiella</i> Phages for Phage Therapy.

ABSTRACT: Introduction: Klebsiella is a clinically important pathogen causing a variety of antimicrobial resistant infections in both community and nosocomial settings, particularly pneumonia, urinary tract infection, and sepsis. Bacteriophage (phage) therapy is being considered a primary option for the treatment of drug-resistant infections of these types. Methods: We report the successful isolation and characterization of 30 novel, genetically diverse Klebsiella phages. Results: The isolated phages span six different phage families and nine genera, representing both lysogenic and lytic lifestyles. Individual Klebsiella phage isolates infected up to 11 of the 18 Klebsiella capsule types tested, and all 18 capsule-types were infec

SUBMITTER: Townsend EM 

PROVIDER: S-EPMC8006926 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature