Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage.

ABSTRACT:

Background

Cold storage of platelets (PLTs) has the potential advantage of prolonging storage time while reducing posttransfusion infection given the decreased likelihood of bacterial outgrowth during storage and possibly beneficial effects in treating bleeding patients. However, cold storage reduces PLT survival through the induction of complex storage lesions, which are more accentuated when storage is prolonged.

Study design and methods

Whole blood-derived PLT-rich plasma concentrates from seven PLT pools (n = 5 donors per pool). PLT additive solution was added (67%/33% plasma) and the product was split into 50-mL bags. Split units were stored in the presence or absence of 1 mM of N-acetylcysteine (NAC) under agitation for up to 14 days at room temperature or in the cold

SUBMITTER: Hegde S 

PROVIDER: S-EPMC8006927 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature