Lipidomic Perturbations in Cynomolgus Monkeys are Regulated by Thyroid Stimulating Hormone.

ABSTRACT: Thyroid disease affects an estimated 200 million people worldwide, and is commonly associated with increased blood lipid levels. However, the mechanism by which thyroid-stimulating hormone (TSH) affects lipid profiles is not clear. Twenty-four cynomolgus monkeys were treated with a novel exogenous recombinant human TSH (rhTSH) (SNA001) at 9 μg kg^-1, 22 μg kg^-1, or 54 μg kg^-1, and reference rhTSH (Thyrogen^®) at 22 μg kg^-1. The primary TSH (SNA001) pharmacokinetic (PK) parameters increased in a dose-dependent manner across the dose range of 9 μg kg^-1, 22 μg kg^-1, or 54 μg kg^-1. Peak triiodothyronine (T3) and thyroxine (T4) levels were reached within 24 h after rhTSH administration, which was delayed by ap

SUBMITTER: Xu T 

PROVIDER: S-EPMC8006939 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature