Brief report: Lymph node morphology in stage II colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is one of the leading causes of cancer-associated morbidity and mortality worldwide. The local anti-tumour immune response is particularly important for patients with stage II where the tumour-draining lymph nodes have not yet succumbed to tumour spread. The lymph nodes allow for the expansion and release of B cell compartments such as primary follicles and germinal centres. A variation in this anti-tumour immune response may influence the observed clinical heterogeneity in stage II patients.

Aim

The aim of this study was to explore tumour-draining lymph node histomorphological changes and tumour pathological risk factors including the immunomodulatory microRNA-21 (miR-21) in a small cohort of stage II CRC.

Methods

A total of 23 stage II c

SUBMITTER: Greenwood A 

PROVIDER: S-EPMC8007027 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature