COPB2: A Novel Prognostic Biomarker That Affects Progression of HCC.

ABSTRACT:

Purpose

This study is aimed at investigating the expression, underlying biological function, and clinical significance of coatomer protein complex subunit beta 2 (COPB2) in hepatocellular carcinoma (HCC).

Methods

HCC-related data were extracted from The Cancer Genome Atlas (TCGA) database, International Cancer Genome Consortium (ICGC) database, and Gene Expression Omnibus (GEO) database. A logistic regression module was applied to analyze the relationship between the expression of COPB2 and clinicopathologic characteristics. The Cox proportional hazard regression model and Kaplan-Meier method were used for survival analysis. Gene set enrichment analysis (GSEA) was used to annotate the underlying biological functions. Loss-of-function experiments were conducted to determine t

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8007342 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature