Single-nucleotide polymorphism-based epidemiological analysis of Korean Mycobacterium bovis isolates.

ABSTRACT:

Background

Bovine tuberculosis (TB) is caused by Mycobacterium bovis, a well-known cause of zoonotic tuberculosis in cattle and deer, and has been investigated in many physiological and molecular studies. However, detailed genome-level studies of M. bovis have not been performed in Korea.

Objectives

To survey whole genome-wide single-nucleotide polymorphism (SNP) variants in Korean M. bovis field isolates and to define M. bovis groups in Korea by comparing SNP typing with spoligotyping and variable number tandem repeat typing.

Methods

A total of 46 M. bovis field isolates, isolated from laryngopharyngeal lymph nodes and lungs of Korean cattle, wild boar, and Korean water deer, were used to identify SNPs by performing whole-genome seq

SUBMITTER: Kim TW 

PROVIDER: S-EPMC8007439 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature