Region-specific regulation of central histaminergic H3 receptor expression in a mouse model of cow's milk allergy.

ABSTRACT: Central histaminergic H3 receptor (H3R) has been extensively investigated as a potential therapeutic target for various neurological and neurodegenerative disorders. Despite promising results in preclinical rodent models, clinical trials have not provided conclusive evidence for the benefit of H3R antagonists to alleviate cognitive and behavioral symptoms of these disorders. Inconsistent pharmacological efficacies may arise from aberrant changes in H3R over time during disease development. Because H3R is involved in feedback inhibition of histamine synthesis and secretion, the expression of the autoreceptor may also be reciprocally regulated by altered histamine levels in a pathological condition. Thus, we investigated H3R expression in a mouse model of cow's milk allergy, a condition asso

SUBMITTER: Germundson DL 

PROVIDER: S-EPMC8007474 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature