Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study.

ABSTRACT:

Background

Postoperative delirium (POD) is a frequent and serious complication after surgery. Evidence of a relationship between anticholinergic medication and the development of delirium is inconclusive, but studies on POD are rare.

Objectives

The objective of this study was to evaluate the anticholinergic load of preoperative medication in older adult patients and its association with the development of POD.

Methods

This investigation was part of the European BioCog project ( http://www.biocog.eu ), a prospective multicenter observational study in older adult surgical patients (ClinicalTrials.gov identifier: NCT02265263, 15 October 2014). Patients with a Mini-Mental State Examination score ≤ 23 points were excluded. POD was assessed up to 7 days after surgery using

SUBMITTER: Heinrich M 

PROVIDER: S-EPMC8007502 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature