Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison.

ABSTRACT: Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad range of compounds and, therefore, is frequently applied in the pharmaceutical industry. Pharmacokinetic and toxicological studies deploy MSI to localize potential drugs and their metabolites in biological tissues but currently require other analytical tools to quantify these pharmaceutical compounds in the same tissues. Quantitative mass spectrometry imaging (Q-MSI) is a field with challenges due to the high biological variability in samples combined with the limited sample cleanup and separation strategies available prior to MSI. In consequence, more selectivity in MSI instruments is required. This can be provided by multiple reaction monitoring (MRM) which uses specific precursor ion-product ion

SUBMITTER: Lamont L 

PROVIDER: S-EPMC8007509 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature