Assessment of Drug Delivery Kinetics to Epidermal Targets In Vivo.

ABSTRACT: It has proven challenging to quantify 'drug input' from a formulation to the viable skin because the epidermal and dermal targets of topically applied drugs are difficult, if not impossible, to access in vivo. Defining the drug input function to the viable skin with a straightforward and practical experimental approach would enable a key component of dermal pharmacokinetics to be characterised. It has been hypothesised that measuring drug uptake into and clearance from the stratum corneum (SC) by tape-stripping allows estimation of a topical drug's input function into the viable tissue. This study aimed to test this idea by determining the input of nicotine and lidocaine into the viable skin, following the application of commercialised transdermal patches to healthy human volunteers. The k

SUBMITTER: Hoppel M 

PROVIDER: S-EPMC8007522 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature