Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors.

ABSTRACT:

Background

Increased sarcoma and melanoma risks after hereditary retinoblastoma are well established, whereas less is known about epithelial subsequent malignant neoplasms (SMNs) and risks for multiple (≥2) SMNs.

Methods

Leveraging long-term follow-up and detailed histologic information, we quantified incident SMN risk among 1128 hereditary and 924 nonhereditary retinoblastoma survivors (diagnosed 1914-2006; follow-up through 2016). Standardised incidence ratios (SIRs) compared cancer risk after retinoblastoma relative to the general population. We estimated cumulative incidence accounting for competing risk of death.

Results

Hereditary survivors had statistically significantly increased SMN risk (N = 239; SIR = 11.9; 95% confidence interval [CI] 10.4-13.5), with SIRs

SUBMITTER: Schonfeld SJ 

PROVIDER: S-EPMC8007574 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature