Genetic factors influencing a neurobiological substrate for psychiatric disorders.

ABSTRACT: A retrospective meta-analysis of magnetic resonance imaging voxel-based morphometry studies proposed that reduced gray matter volumes in the dorsal anterior cingulate and the left and right anterior insular cortex-areas that constitute hub nodes of the salience network-represent a common substrate for major psychiatric disorders. Here, we investigated the hypothesis that the common substrate serves as an intermediate phenotype to detect genetic risk variants relevant for psychiatric disease. To this end, after a data reduction step, we conducted genome-wide association studies of a combined common substrate measure in four population-based cohorts (n = 2271), followed by meta-analysis and replication in a fifth cohort (n = 865). After correction for covariates, the heritability of the comm

SUBMITTER: Andlauer TFM 

PROVIDER: S-EPMC8007575 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature