Polygenic risk score, healthy lifestyles, and risk of incident depression.

ABSTRACT: Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of genetic risk. Data were obtained from the UK Biobank and consisted of 339,767 participants (37-73 years old) without depression between 2006 and 2010. Genetic risk was categorized as low, intermediate, or high according to polygenic risk score for depression. A combination of healthy lifestyles factors-including no current smoking, regular physical activity, a healthy diet, moderate alcohol intake and a body mass index <30 kg/m²-was categorized into favorable, intermediate, and unfavorable lifestyles. The risk of depression was 2

SUBMITTER: Cao Z 

PROVIDER: S-EPMC8007584 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature