Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study.

ABSTRACT:

Background

We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorectal cancer risk and to understand the contributions of effects mediated through changes in body fat.

Methods

Common genetic variants associated with self-reported moderate-to-vigorous PA (MVPA), acceleration vector magnitude PA (AMPA) and sedentary time were used as instrumental variables. To control for confounding effects of obesity, we included instrumental variables for body mass index (BMI), body fat percentage, waist circumference and arm, trunk and leg fat ratios. We analysed the effect of these instrumental variables in a colorectal cancer genome-wide association study comprising 31,197 cases and 61,770 controls of European ancestry

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8007642 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature