Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.

ABSTRACT:

Background & aims

Esophageal remodeling in eosinophilic esophagitis (EoE) can lead to esophageal rigidity with eventual luminal compromise and stenoses. Gauging esophageal functional alterations in EoE is challenging. An epithelial marker of functional remodeling would impact EoE management.

Methods

Esophageal biopsy specimens from children with and without EoE and primary human esophageal epithelial cells were used for PAI-1 immunohistochemistry, and cell proliferation experiments. PAI-1 immunostaining and basal cell hyperplasia were assessed in the context of concurrently obtained esophageal compliance measures on endoscopic functional lumen imaging probe (EndoFLIP).

Results

EndoFLIPs were performed in 45 children (32 with and 13 without EoE). Epithelial PAI-1 was i

SUBMITTER: Williamson P 

PROVIDER: S-EPMC8007666 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature