The gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs.

ABSTRACT: Inflammation is a natural defense process of the innate immune system, associated with the release of proinflammatory cytokines such as interleukin-1β, interleukin-6, interleukin-12 and TNFα; and enzymes including iNOS through the activation and nuclear translocation of NF-κB p65 due to the phosphorylation of IκBα. Regulation of intracellular Ca²⁺ is considered a promising strategy for the prevention of reactive oxygen species (ROS) production and accumulation of DNA double strand breaks (DSBs) that occurs in inflammatory-associated-diseases. Among the metabolites of ellagitannins that are produced in the gut microbiome, urolithin A (UA) has received an increasing attention as a novel candidate with anti-inflammatory and anti-oxidant effects. Here, we investigated the effect of

SUBMITTER: Abdelazeem KNM 

PROVIDER: S-EPMC8007722 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature