Insights into Acinetobacter baumannii fatty acid synthesis 3-oxoacyl-ACP reductases.

ABSTRACT: Treatments for 'superbug' infections are the focus for innovative research, as drug resistance threatens human health and medical practices globally. In particular, Acinetobacter baumannii (Ab) infections are repeatedly reported as difficult to treat due to increasing antibiotic resistance. Therefore, there is increasing need to identify novel targets in the development of different antimicrobials. Of particular interest is fatty acid synthesis, vital for the formation of phospholipids, lipopolysaccharides/lipooligosaccharides, and lipoproteins of Gram-negative envelopes. The bacterial type II fatty acid synthesis (FASII) pathway is an attractive target for the development of inhibitors and is particularly favourable due to the differences from mammalian type I fatty acid synthesis. Discre

SUBMITTER: Cross EM 

PROVIDER: S-EPMC8007833 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature