Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer.

ABSTRACT: Estrogen signaling is crucial for breast cancer initiation and progression. Endocrine-based therapies comprising estrogen receptor (ER) modulators and aromatase inhibitors remain the mainstay of treatment. This study aimed at investigating the antitumor potential of the most potent compounds in citrus peels on breast cancer by exploring their anti-estrogenic and anti-aromatase activities. The ethanolic extract of different varieties of citrus peels along with eight isolated flavonoids were screened against estrogen-dependent breast cancer cell lines besides normal cells for evaluating their safety profile. Naringenin, naringin and quercetin demonstrated the lowest IC_50s and were therefore selected for further assays. In silico molecular modeling against ER and aromatase was perf

SUBMITTER: El-Kersh DM 

PROVIDER: S-EPMC8007834 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature