Erythropoietin in Lupus: Unanticipated Immune Modulating Effects of a Kidney Hormone.

ABSTRACT: Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease with variable clinical presentation, typically characterized by a relapsing-remitting course. SLE has a multifactorial pathogenesis including genetic, environmental, and hormonal factors that lead to loss of tolerance against self-antigens and autoantibody production. Mortality in SLE patients remains significantly higher than in the general population, in part because of the limited efficacy of available treatments and the associated toxicities. Therefore, novel targeted therapies are urgently needed to improve the outcomes of affected individuals. Erythropoietin (EPO), a kidney-produced hormone that promotes red blood cell production in response to hypoxia, has lately been shown to also possess non-erythropoietic prope

SUBMITTER: Eswarappa M 

PROVIDER: S-EPMC8007959 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature