On the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?

ABSTRACT: Cellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential expression and the variety of post-transcriptional modifications they are subject to, lead to the existence of complex repertoires of tRNA populations adjusted to defined cellular states. Despite the tRNA-coding genes redundancy in prokaryote and eukaryote genomes, it is surprising to note the absence of genes coding specific translational-active isoacceptors throughout the phylogeny. Through the analysis of different releases of tRNA databases, this review aims to provide a general summary about those "missing tRNA genes." This absence re

SUBMITTER: Ehrlich R 

PROVIDER: S-EPMC8007984 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature