Resequencing of Microbial Isolates: A Lab Module to Introduce Novices to Command-Line Bioinformatics.

ABSTRACT: Familiarity with genome-scale data and the bioinformatic skills to analyze it have become essential for understanding and advancing modern biology and human health, yet many undergraduate biology majors are never exposed to hands-on bioinformatics. This paper presents a module that introduces students to applied bioinformatic analysis within the context of a research-based microbiology lab course. One of the most commonly used genomic analyses in biology is resequencing: determining the sequence of DNA bases in a derived strain of some organism, and comparing it to the known ancestral genome of that organism to better understand the phenotypic differences between them. Many existing CUREs - Course Based Undergraduate Research Experiences - evolve or select new strains of bacteria and compa

SUBMITTER: Petrie KL 

PROVIDER: S-EPMC8008064 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature