Staphylococcus aureus-Specific Tissue-Resident Memory CD4⁺ T Cells Are Abundant in Healthy Human Skin.

ABSTRACT: The skin is an immunocompetent tissue that harbors several kinds of immune cells and a plethora of commensal microbes constituting the skin microbiome. Staphylococcus aureus is a prominent skin pathogen that colonizes a large proportion of the human population. We currently have an incomplete understanding of the correlates of protection against S. aureus infection, however genetic and experimental evidence has shown that CD4⁺ T cells play a key role in orchestrating a protective anti-S. aureus immune response. A high S. aureus-specific memory CD4⁺ T cell response has been reported in the blood of healthy subjects. Since T cells are more abundant in the skin than in blood, we hypothesized that S. aureus-specific CD4⁺ T cel

SUBMITTER: Hendriks A 

PROVIDER: S-EPMC8008074 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature