Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications.

ABSTRACT: Metabolic dysregulation in the tumor microenvironment has significant impact on immune infiltration and immune responses. However, interaction between immunity and metabolism in the ovarian microenvironment requires further exploration. We constructed an immunometabolism gene set and ovarian cancer cohort from The Cancer Genome Atlas (TCGA) and classified these into three immunometabolism subtypes. We explored the relationships between immune infiltration and metabolic reprogramming. Additionally, we built risk score and nomogram as prognostic signatures. Three distinctive immunometabolism subtypes were identified with therapeutic and prognostic implications. Subtype 1, the "immune suppressive-glycan metabolism subtype," featured high levels of immunosuppressive cell infiltration and glyca

SUBMITTER: Yang M 

PROVIDER: S-EPMC8008085 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature