M⁶A RNA Methylation Regulators Impact Prognosis and Tumor Microenvironment in Renal Papillary Cell Carcinoma.

ABSTRACT: Accumulating evidence has proven that N6-methyladenosine (m⁶A) RNA methylation plays an essential role in tumorigenesis. However, the significance of m⁶A RNA methylation modulators in the malignant progression of papillary renal cell carcinoma (PRCC) and their impact on prognosis has not been fully analyzed. The present research set out to explore the roles of 17 m⁶A RNA methylation regulators in tumor microenvironment (TME) of PRCC and identify the prognostic values of m⁶A RNA methylation regulators in patients afflicted by PRCC. We investigated the different expression patterns of the m⁶A RNA methylation regulators between PRCC tumor samples and normal tissues, and systematically explored the association of the expression patterns of

SUBMITTER: Chen L 

PROVIDER: S-EPMC8008109 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature