Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue.

ABSTRACT: Fertility preservation represents one important goal of cancer patients' management due to the high impact on health and quality of life of survivors. The available preventive measures cannot be performed in all patients and are not feasible in all health-care facilities. Therefore, the pharmacological treatment with GnRHa has become a valuable non-invasive and well-tolerated alternative, especially in those who cannot access to cryopreservation options due to clinical and/or logistic issues. Supporting data demonstrate a significant advantage for the survivors who received GnRHa in the long-term maintenance of ovarian function and preservation of fertility. The prevention of the risk of ovarian failure with GnRHa is a typical off-label use, defined as the administration of a medicinal pro

SUBMITTER: Brancati S 

PROVIDER: S-EPMC8008167 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature