Multilayer Alginate-Polycaprolactone Electrospun Membranes as Skin Wound Patches with Drug Delivery Abilities.

ABSTRACT: A multilayer nanofibrous membrane consisting of a layer of polycaprolactone and one of physically cross-linked alginate-embedding ZnO nanoparticles is prepared via electrospinning technique as potential wound healing patches with drug delivery capabilities. A washing-cross-linking protocol is developed to obtain stable materials at the same time removing poly(ethylene oxide), which was used here as a cospinning agent for alginate, without interfering with the membrane's peculiar nanofibrous structure. The mechanical behavior of the samples is assessed via a uniaxial tensile test showing appropriate resistance and manageability together with a good thermal stability as proved via thermogravimetric analysis. The polycaprolactone external layer enriches the samples with good liquid-repellent

SUBMITTER: Dodero A 

PROVIDER: S-EPMC8008386 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature