BMI Is Causally Associated With Pulmonary Artery Pressure But Not Hemodynamic Evidence of Pulmonary Vascular Remodeling.

ABSTRACT:

Background

There is an unclear relationship of obesity to the pathogenesis and severity of pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH).

Research question

Is BMI casually associated with pulmonary artery pressure (PAP) and/or markers of pulmonary vascular remodeling?

Study design and methods

The study design was a two-sample inverse-variance weighted Mendelian randomization. We constructed two BMI genetic risk scores from genome-wide association study summary data and deployed them in nonoverlapping cohorts of subjects referred for right heart catheterization (RHC) or echocardiography. A BMI highly polygenic risk score (hpGRS) optimally powered to detect shared genetic architecture of obesity with other traits was tested for associatio

SUBMITTER: Thayer TE 

PROVIDER: S-EPMC8008481 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature