Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability.

ABSTRACT: Amyloid-β (Aβ) misfolding is one of the hallmark pathological features of Alzheimer's disease (AD). AD can manifest with diverse symptomatology including variable rates of cognitive decline, duration of clinical disease, and other detrimental changes. Several reports suggest that conformational diversity in misfolded Aβ is a leading factor for clinical variability in AD, analogous to what it has been described for prion strains in prion diseases. Notably, prion strains generate diverse patterns of misfolded protein deposition in the brains of affected individuals. Here, we tested the in vivo prion-like transmission features of four AD brains displaying particular patterns of amyloidosis. AD brains induced different phenotypes in recipient mice, as evaluated by their specific seeding activi

SUBMITTER: Duran-Aniotz C 

PROVIDER: S-EPMC8008576 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature