Thousands of previously unknown phages discovered in whole-community human gut metagenomes.

ABSTRACT:

Background

Double-stranded DNA bacteriophages (dsDNA phages) play pivotal roles in structuring human gut microbiomes; yet, the gut virome is far from being fully characterized, and additional groups of phages, including highly abundant ones, continue to be discovered by metagenome mining. A multilevel framework for taxonomic classification of viruses was recently adopted, facilitating the classification of phages into evolutionary informative taxonomic units based on hallmark genes. Together with advanced approaches for sequence assembly and powerful methods of sequence analysis, this revised framework offers the opportunity to discover and classify unknown phage taxa in the human gut.

Results

A search of human gut metagenomes for circular contigs encoding phage hallmark gen

SUBMITTER: Benler S 

PROVIDER: S-EPMC8008677 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature