Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease.

ABSTRACT:

Background

To investigate the association of plasma pTau181, assessed with a new immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and longitudinally, in aging and Alzheimer's disease.

Methods

Observational data was obtained from the Alzheimer's Disease Neuroimaging Initiative, in which participants underwent plasma assessment and magnetic resonance imaging. Based on their clinical diagnosis, participants were classified as cognitively unimpaired and cognitively impaired. Linear regressions and linear mixed-effect models were used to test the cross-sectional and longitudinal associations between baseline plasma pTau181 and neurodegeneration using voxel-based morphometry.

Results

We observed a negative correlation at baseline between

SUBMITTER: Tissot C 

PROVIDER: S-EPMC8008680 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature