An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves.

ABSTRACT: Valvular heart diseases are complex disorders, varying in pathophysiological mechanism and affected valve components. Understanding the effects of these diseases on valve functionality requires a thorough characterization of the mechanics and structure of the healthy heart valves. In this study, we performed biaxial mechanical experiments with extensive testing protocols to examine the mechanical behaviors of the mitral valve and tricuspid valve leaflets. We also investigated the effect of loading rate, testing temperatures, species (porcine versus ovine hearts), and age (juvenile vs adult ovine hearts) on the mechanical responses of the leaflet tissues. In addition, we evaluated the structure of chordae tendineae within each valve and performed histological analysis on each atrioventricul

SUBMITTER: Jett S 

PROVIDER: S-EPMC8008704 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature