Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.

ABSTRACT:

Background

Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to compare genetic variation in women with invasive cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 with that in healthy controls.

Methods

We did a GWAS in a cohort of unrelated European individuals using data from UK Biobank, a population-based cohort including 273 377 women aged 40-69 years at recruitment between Marc

SUBMITTER: Bowden SJ 

PROVIDER: S-EPMC8008734 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature