Different forms of traumatic brain injuries cause different tactile hypersensitivity profiles.

ABSTRACT:

Abstract

Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been understudied, in large part because of the lack of well-characterized laboratory animal models. We have addressed this gap in the field by characterizing the tactile sensory profile of 2 nonpenetrating models of PTH. We show that multimodal traumatic brain injury, administered by a jet-flow overpressure chamber that delivers a severe compressive impulse accompanied by a variable shock front and acceleration-deceleration insult, produces long-term tactile hypers

SUBMITTER: Wattiez AS 

PROVIDER: S-EPMC8008742 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature