The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.

ABSTRACT: The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.

SUBMITTER: Zacarias-Fluck MF 

PROVIDER: S-EPMC8008953 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature