Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study.

ABSTRACT:

Objective

To compare the risk of cardiovascular events between sodium glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors among people with type 2 diabetes in a real world context of clinical practice.

Design

Multi-database retrospective cohort study using a prevalent new user design with subsequent meta-analysis.

Setting

Canadian Network for Observational Drug Effect Studies (CNODES), with administrative healthcare databases from seven Canadian provinces and the United Kingdom, 2013-18.

Population

209 867 new users of a SGLT2 inhibitor matched to 209 867 users of a DPP-4 inhibitor on time conditional propensity score and followed for a mean of 0.9 years.

Main outcome measures

The primary outcome was major adverse car

SUBMITTER: Filion KB 

PROVIDER: S-EPMC8009082 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature