Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial.

ABSTRACT:

Background

Cancer is a leading cause of death globally. Given the elevated risk of cancer with age and an ageing population, it is important to understand the changing burden of cancer in older populations. The ASPirin in Reducing Events in the Elderly (ASPREE) study randomised healthy older individuals to 100 mg aspirin or placebo, with clinical outcomes and disability-free survival endpoints. Detailed baseline data provides a rare opportunity to explore cancer burden in a uniquely healthy older population.

Methods

At study enrolment (2010-2014), self-reported personal cancer history, cancer type and cancer risk factor data were sought from 19,114 participants (Australia, n = 16,703; U.S., n = 2411). Eligible participants were healthy, free of major diseases and expected to

SUBMITTER: Orchard SG 

PROVIDER: S-EPMC8009087 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature