A genome wide association study for lung function in the Korean population using an exome array.

ABSTRACT:

Background/aims

Lung function is an objective indicator of diagnosis and prognosis of respiratory diseases. Many common genetic variants have been associated with lung function in multiple ethnic populations. We looked for coding variants associated with forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC) in the Korean general population.

Methods

We carried out exome array analysis and lung function measurements of the FEV1 and FEV1/FVC in 7,524 individuals of the Korean population. We evaluated single variants with minor allele frequency greater than 0.5%. We performed look-ups for candidate coding variants associations in the UK Biobank, SpiroMeta, and CHARGE consortia.

Results

We identified coding variants in the SMIM29 (C6orf1) (p = 1.

SUBMITTER: Lee KS 

PROVIDER: S-EPMC8009153 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature