Hydrogen sulfide-releasing micelles for promoting angiogenesis.

ABSTRACT: Hydrogen sulfide (H₂S), an important gaseous signalling molecule in the human body, has been shown to be involved in many physiological processes such as angiogenesis. Since the biological activities of H₂S are known to be significantly affected by the dose and exposure duration, the development of H₂S delivery systems that enable control of H₂S release is critical for exploring its therapeutic potential. Here, we prepared polymeric micelles with different H₂S release profiles, which were prepared from amphiphilic block copolymers consisting of a hydrophilic poly(N-acryloyl morpholine) segment and a hydrophobic segment containing H₂S-releasing anethole dithiolethione (ADT) groups. The thermodynamic stability of the mi

SUBMITTER: Chen JJY 

PROVIDER: S-EPMC8009299 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature