Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity.

ABSTRACT: The development of safe subunit vaccines requires adjuvants that augment immunogenicity of non-replicating protein-based antigens. Current vaccines against infectious diseases preferentially induce protective antibodies driven by adjuvants such as alum. However, the contribution of antibody to host defense is limited for certain classes of infectious diseases such as fungi, whereas animal studies and clinical observations implicate cellular immunity as an essential component of the resolution of fungal pathogens. Here, we decipher the structural bases of a newly identified glycoprotein ligand of Dectin-2 with potent adjuvancy, Blastomyces endoglucanase-2 (Bl-Eng2). We also pinpoint the developmental steps of antigen-specific CD4+ and CD8+ T responses augmented by Bl-Eng2 including expansio

SUBMITTER: Dos Santos Dias L 

PROVIDER: S-EPMC8009368 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature