Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and anti-oxidant properties which have been shown to be relevant to the pathophysiology of depression. This study assesses the efficacy, acceptability, tolerability, and safety of statins in major depressive disorder.

Methods

Our study is an update and extension of a previous meta-analysis published in 2016 by Salagre et al. We performed a systematic review (PubMed/MEDLINE, Cochrane CENTRAL, ISI Web of Science, CINAHL, and ClinicalTrials.gov until the 1st September 2020) and meta-analysis of randomized controlled trials using any statin against placebo or

SUBMITTER: De Giorgi R 

PROVIDER: S-EPMC8009386 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature