Effect of the Heteroaromatic Antenna on the Binding of Chiral Eu(III) Complexes to Bovine Serum Albumin.

ABSTRACT: The cationic enantiopure (R,R) and luminescent Eu(III) complex [Eu(bisoQcd)(H₂O)₂] OTf (with bisoQcd = N,N'-bis(2-isoquinolinmethyl)-trans-1,2-diaminocyclohexane N,N'-diacetate and OTf = triflate) was synthesized and characterized. At physiological pH, the 1:1 [Eu(bisoQcd)(H₂O)₂]⁺ species, possessing two water molecules in the inner coordination sphere, is largely dominant. The interaction with bovine serum albumin (BSA) was studied by means of several experimental techniques, such as luminescence spectroscopy, isothermal titration calorimetry (ITC), molecular docking (MD), and molecular dynamics simulations (MDS). In this direction, a ligand competition study was also performed b

SUBMITTER: De Rosa C 

PROVIDER: S-EPMC8009522 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature